@article {3383,
	title = {Persistent beneficial impact of H-reflex conditioning in spinal cord-injured rats.},
	journal = {J Neurophysiol},
	volume = {112},
	year = {2014},
	month = {11/2014},
	pages = {2374-81},
	abstract = {<p>Operant conditioning of a spinal cord reflex can improve locomotion in rats and humans with incomplete spinal cord injury. This study examined the persistence of its beneficial effects. In rats in which a right lateral column contusion injury had produced asymmetric locomotion, up-conditioning of the right soleus H-reflex eliminated the asymmetry while down-conditioning had no effect. After the 50-day conditioning period ended, the H-reflex was monitored for 100 [{\textpm}9 (SD)] (range 79-108) more days and locomotion was then reevaluated. After conditioning ended in up-conditioned rats, the H-reflex continued to increase, and locomotion continued to improve. In down-conditioned rats, the H-reflex decrease gradually disappeared after conditioning ended, and locomotion at the end of data collection remained as impaired as it had been before and immediately after down-conditioning. The persistence (and further progression) of H-reflex increase but not H-reflex decrease in these spinal cord-injured rats is consistent with the fact that up-conditioning improved their locomotion while down-conditioning did not. That is, even after up-conditioning ended, the up-conditioned H-reflex pathway remained adaptive because it improved locomotion. The persistence and further enhancement of the locomotor improvement indicates that spinal reflex conditioning protocols might supplement current therapies and enhance neurorehabilitation. They may be especially useful when significant spinal cord regeneration becomes possible and precise methods for retraining the regenerated spinal cord are needed.</p>},
	keywords = {H-reflex conditioning, Learning, Locomotion, Memory, Motor control, Rehabilitation, spinal cord injury, spinal cord plasticity},
	issn = {1522-1598},
	doi = {10.1152/jn.00422.2014},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25143542},
	author = {Yi Chen and Lu Chen and Wang, Yu and Jonathan Wolpaw and Xiang Yang Chen}
}
@article {3100,
	title = {Reflex conditioning: a new strategy for improving motor function after spinal cord injury.},
	journal = {Annals of the New York Academy of Sciences},
	volume = {1198 Suppl 1},
	year = {2010},
	month = {06/2010},
	pages = {E12{\textendash}E21},
	abstract = {Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.},
	keywords = {H-Reflex, learning and memory, Locomotion, plasticity, reflex conditioning, Rehabilitation, spinal cord injury},
	issn = {1749-6632},
	doi = {10.1111/j.1749-6632.2010.05565.x},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20590534},
	author = {Xiang Yang Chen and Yi Chen and Wang, Yu and Thompson, Aiko and Jonathan S. Carp and Segal, Richard L. and Jonathan Wolpaw}
}
@article {3066,
	title = {Operant conditioning of H-reflex can correct a locomotor abnormality after spinal cord injury in rats.},
	journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
	volume = {26},
	year = {2006},
	month = {11/2006},
	pages = {12537{\textendash}12543},
	abstract = {<p>This study asked whether operant conditioning of the H-reflex can modify locomotion in spinal cord-injured rats. Midthoracic transection of the right lateral column of the spinal cord produced a persistent asymmetry in the muscle activity underlying treadmill locomotion. The rats were then either exposed or not exposed to an H-reflex up-conditioning protocol that greatly increased right soleus motoneuron response to primary afferent input, and locomotion was reevaluated. H-reflex up-conditioning increased the right soleus burst and corrected the locomotor asymmetry. In contrast, the locomotor asymmetry persisted in the control rats. These results suggest that appropriately selected reflex conditioning protocols might improve function in people with partial spinal cord injuries. Such protocols might be especially useful when significant regeneration becomes possible and precise methods for reeducating the regenerated spinal cord neurons and synapses are needed for restoring effective function.</p>},
	keywords = {H-reflex conditioning, Learning, Locomotion, Memory, Motor control, Rehabilitation, spinal cord injury, spinal cord plasticity},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.2198-06.2006},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17135415},
	author = {Yi Chen and Xiang Yang Chen and Jakeman, Lyn B. and Lu Chen and Stokes, Bradford T. and Jonathan Wolpaw}
}
@article {3194,
	title = {The interaction of a new motor skill and an old one: H-reflex conditioning and locomotion in rats.},
	journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
	volume = {25},
	year = {2005},
	month = {07/2005},
	pages = {6898{\textendash}6906},
	abstract = {New and old motor skills can interfere with each other or interact in other ways. Because each skill entails a distributed pattern of activity-dependent plasticity, investigation of their interactions is facilitated by simple models. In a well characterized model of simple learning, rats and monkeys gradually change the size of the H-reflex, the electrical analog of the spinal stretch reflex. This study evaluates in normal rats the interactions of this new skill of H-reflex conditioning with the old well established skill of overground locomotion. In rats in which the soleus H-reflex elicited in the conditioning protocol (i.e., the conditioning H-reflex) had been decreased by down-conditioning, the H-reflexes elicited during the stance and swing phases of locomotion (i.e., the locomotor H-reflexes) were also smaller. Similarly, in rats in which the conditioning H-reflex had been increased by up-conditioning, the locomotor H-reflexes were also larger. Soleus H-reflex conditioning did not affect the duration, length, or right/left symmetry of the step cycle. However, the conditioned change in the stance H-reflex was positively correlated with change in the amplitude of the soleus locomotor burst, and the correlation was consistent with current estimates of the contribution of primary afferent input to the burst. Although H-reflex conditioning and locomotion did not interfere with each other, H-reflex conditioning did affect how locomotion was produced: it changed soleus burst amplitude and may have induced compensatory changes in the activity of other muscles. These results illustrate and clarify the subtlety and complexity of skill interactions. They also suggest that H-reflex conditioning might be used to improve the abnormal locomotion produced by spinal cord injury or other disorders of supraspinal control.},
	keywords = {H-reflex conditioning, Learning, Locomotion, memory consolidation, Motor control, Rehabilitation, spinal cord plasticity},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.1684-05.2005},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16033899},
	author = {Yi Chen and Xiang Yang Chen and Jakeman, Lyn B. and Gerwin Schalk and Stokes, Bradford T. and Jonathan Wolpaw}
}
