@article {4336,
	title = {Modulation in cortical excitability disrupts information transfer in perceptual-level stimulus processing.},
	journal = {Neuroimage},
	volume = {243},
	year = {2021},
	month = {11/2021},
	pages = {118498},
	abstract = {<p>Despite significant interest in the neural underpinnings of behavioral variability, little light has been shed on the cortical mechanism underlying the failure to respond to perceptual-level stimuli. We hypothesized that cortical activity resulting from perceptual-level stimuli is sensitive to the moment-to-moment fluctuations in cortical excitability, and thus may not suffice to produce a behavioral response. We tested this hypothesis using electrocorticographic recordings to follow the propagation of cortical activity in six human subjects that responded to perceptual-level auditory stimuli. Here we show that for presentations that did not result in a behavioral response, the likelihood of cortical activity decreased from auditory cortex to motor cortex, and was related to reduced local cortical excitability. Cortical excitability was quantified using instantaneous voltage during a short window prior to cortical activity onset. Therefore, when humans are presented with an auditory stimulus close to perceptual-level threshold, moment-by-moment fluctuations in cortical excitability determine whether cortical responses to sensory stimulation successfully connect auditory input to a resultant behavioral response.</p>},
	keywords = {Acoustic Stimulation, Adult, Aged, Alpha Rhythm, Auditory Cortex, Brain Mapping, Cortical Excitability, Electrocorticography, Female, Humans, Male, Middle Aged},
	issn = {1095-9572},
	doi = {10.1016/j.neuroimage.2021.118498},
	author = {Moheimanian, Ladan and Paraskevopoulou, Sivylla E and Adamek, Markus and Schalk, Gerwin and Peter Brunner}
}
