01883nas a2200217   4500008004100000022001400041245011000055210006900165260001200234300001100246490000900257520120500266100002001471700002401491700002101515700002601536700001901562700001501581700002101596856004801617       2013                        eng d  a1557-170X00aCortiQ - clinical software for electrocorticographic real-time functional mapping of the eloquent cortex.0 aCortiQ clinical software for electrocorticographic realtime func  c07/2013  a6365-80 v20133 aPlanning for epilepsy surgery depends substantially on the localization of brain cortical areas responsible for sensory, motor, or cognitive functions, clinically also known as eloquent cortex. In this paper, we present the novel software package 'cortiQ' that allows clinicians to localize eloquent cortex, thus providing a safe margin for surgical resection with a low incidence of neurological deficits. This software can be easily used in addition to traditional mapping procedures such as the electrical cortical stimulation (ECS) mapping. The software analyses task-related changes in gamma activity recorded from implanted subdural electrocorticography electrodes using extensions to previously published methods. In this manuscript, we describe the system's architecture and workflow required to obtain a map of the eloquent cortex. We validate the system by comparing our mapping results with those acquired using ECS mapping in two subjects. Our results indicate that cortiQ reliably identifies eloquent cortex much faster (several minutes compared to an hour or more) than ECS mapping. Next-neighbour analyses show that there are no false positives and an average of 1.24% false negatives.1 aPrueckl, Robert1 aKapeller, Christoph1 aPotes, Cristhian1 aKorostenskaja, Milena1 aSchalk, Gerwin1 aLee, Ki, H1 aGuger, Christoph  uhttp://www.ncbi.nlm.nih.gov/pubmed/24111197