02238nas a2200325 4500008004100000022001400041245007500055210006900130260001200199300001200211490000700223520137400230653001001604653001801614653001101632653001101643653000901654653001601663653001701679653001301696100002001709700001901729700001901748700002101767700002601788700001301814700002001827700001701847856004801864 2007 eng d a1529-240100aSpectral Changes in Cortical Surface Potentials During Motor Movement.0 aSpectral Changes in Cortical Surface Potentials During Motor Mov c02/2007 a2424-320 v273 a

In the first large study of its kind, we quantified changes in electrocorticographic signals associated with motor movement across 22 subjects with subdural electrode arrays placed for identification of seizure foci. Patients underwent a 5-7 d monitoring period with array placement, before seizure focus resection, and during this time they participated in the study. An interval-based motor-repetition task produced consistent and quantifiable spectral shifts that were mapped on a Talairach-standardized template cortex. Maps were created independently for a high-frequency band (HFB) (76-100 Hz) and a low-frequency band (LFB) (8-32 Hz) for several different movement modalities in each subject. The power in relevant electrodes consistently decreased in the LFB with movement, whereas the power in the HFB consistently increased. In addition, the HFB changes were more focal than the LFB changes. Sites of power changes corresponded to stereotactic locations in sensorimotor cortex and to the results of individual clinical electrical cortical mapping. Sensorimotor representation was found to be somatotopic, localized in stereotactic space to rolandic cortex, and typically followed the classic homunculus with limited extrarolandic representation.

10aAdult10aBrain Mapping10aFemale10aHumans10aMale10aMiddle Aged10aMotor Cortex10aMovement1 aMiller, John, W1 aLeuthardt, E C1 aSchalk, Gerwin1 aRao, Rajesh, P N1 aAnderson, Nicholas, R1 aMoran, D1 aMiller, John, W1 aOjemann, J G uhttp://www.ncbi.nlm.nih.gov/pubmed/17329441