01697nas a2200229   4500008004100000022001400041245009400055210006900149260001200218300001400230490000700244520103100251653001401282653002501296653001501321653001001336100001301346700002301359700002201382700001501404856004801419       2002                        eng d  a0024-320500aCorticospinal transmission to motoneurons in cervical spinal cord slices from adult rats.0 aCorticospinal transmission to motoneurons in cervical spinal cor  c12/2002  a389–3960 v723 aCervical spinal cord slices were prepared from adult rats. Intracellular recordings from motoneurons revealed that electrical stimulation of the ventralmost part of the dorsal funiculus (which contains primarily descending corticospinal axons) elicited EPSPs in 75% of the neurons. The latencies of these EPSPs tended to be shorter than those elicited by dorsal horn gray matter stimulation. Pairs of subthreshold dorsal funiculus stimuli were able to elicit action potentials in motoneurons. These data are consistent with previous morphological and electrophysiological studies indicating that cervical motoneurons receive both mono-and polysynaptic corticospinal inputs. In addition, motoneurons were markedly depolarized by iontophoretic application of AMPA or KA (7 out of 7 neurons), but only weakly depolarized by NMDA (1 out of 6 neurons). CNQX (but not AP-5) blocked EPSPs elicited by dorsal funiculus stimulation. Thus, corticospinal transmission to motoneurons is mediated primarily by non-NMDA glutamate receptors.10aadult rat10acervical spinal cord10amotoneuron10aslice1 aHori, N.1 aCarp, Jonathan, S.1 aCarpenter, D., O.1 aAkaike, N.  uhttp://www.ncbi.nlm.nih.gov/pubmed/12467879