01836nas a2200193   4500008004100000022001400041245009100055210006900146260001200215300001400227490000700241520124500248653001901493653001401512653002601526100002301552700002101575856004601596       1979                        eng d  a0091-305700aSensorimotor deficits produced by phenytoin and chlorpromazine in unanesthetized cats.0 aSensorimotor deficits produced by phenytoin and chlorpromazine i  c04/1979  a513–5200 v103 aUnanesthetized adult cats were evaluated for suprasegmental reflex activity and motor skills before and after administration of chlorpromazine (0.0625–0.5 mg/kg) alone and in combination with phenytoin (20 mg/kg). The greatest deficits were seen in the tests of balance and corrdination in which half the animals failed to match their control responses after administration of chlorpromazine and phenytoin. The impairment was most noticeable with the most stringent test (walking a 4 cm wide beam), and the effects of the two drugs were additive. Although there was no effect of either drug on muscle strength, the two drugs in combination depressed the animals' motivational state, making them less willing to work against imposed loads. Neither drug, alone or in combination, altered responses to the flexor reflex, blind placing, the hopping response or visually aided placing. It is concluded that the effects of chlorpromazine and phenytoin on motor control are selective for the CNS loci which control balance and coordination. Although the two drugs produce additive responses, the deficits occur only at doses which are well above those needed for clinical efficacy and thus may not pose a problem in their long term clinical use.10aChlorpromazine10aPhenytoin10aSensorimotor deficits1 aCarp, Jonathan, S.1 aAnderson, R., J.  uhttp://www.ncbi.nlm.nih.gov/pubmed/461481