02500nas a2200385   4500008004100000022001400041245010500055210006900160260001600229300000900245490000700254520128700261653003001548653001701578653002701595653001101622653002501633653001801658653004601676653001901722100002201741700001901763700001701782700001301799700001901812700001601831700002201847700001801869700002301887700002101910700001901931700002401950700002301974856011701997       2024                        eng d  a2045-232200aA novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study.0 anovel thetacontrolled vibrotactile braincomputer interface to tr  c2024 Feb 10  a34330 v143 a<p>Limitations in chronic pain therapies necessitate novel interventions that are effective, accessible, and safe. Brain-computer interfaces (BCIs) provide a promising modality for targeting neuropathology underlying chronic pain by converting recorded neural activity into perceivable outputs. Recent evidence suggests that increased frontal theta power (4-7 Hz) reflects pain relief from chronic and acute pain. Further studies have suggested that vibrotactile stimulation decreases pain intensity in experimental and clinical models. This longitudinal, non-randomized, open-label pilot study's objective was to reinforce frontal theta activity in six patients with chronic upper extremity pain using a novel vibrotactile neurofeedback BCI system. Patients increased their BCI performance, reflecting thought-driven control of neurofeedback, and showed a significant decrease in pain severity (1.29 ± 0.25 MAD, p = 0.03, q = 0.05) and pain interference (1.79 ± 1.10 MAD p = 0.03, q = 0.05) scores without any adverse events. Pain relief significantly correlated with frontal theta modulation. These findings highlight the potential of BCI-mediated cortico-sensory coupling of frontal theta with vibrotactile stimulation for alleviating chronic pain.</p>10abrain-computer interfaces10aChronic Pain10aElectroencephalography10aHumans10aLongitudinal Studies10aNeurofeedback10aNon-Randomized Controlled Trials as Topic10aPilot Projects1 aDemarest, Phillip1 aRustamov, Nabi1 aSwift, James1 aXie, Tao1 aAdamek, Markus1 aCho, Hohyun1 aWilson, Elizabeth1 aHan, Zhuangyu1 aBelsten, Alexander1 aLuczak, Nicholas1 aBrunner, Peter1 aHaroutounian, Simon1 aLeuthardt, Eric, C  uhttps://neurotechcenter.org/publications/2024/novel-theta-controlled-vibrotactile-brain-computer-interface-treat00790nas a2200229   4500008004100000245010600041210007100147300000900218490000700227100002200234700001900256700001700275700001300292700001900305700001600324700002200340700001800362700002300380700002100403700001100424856012500435       2024                        eng d00aA novel theta-controlled vibrotactile brain–computer interface to treat chronic pain: a pilot study0 anovel thetacontrolled vibrotactile brain–computer interface to t  a34330 v141 aDemarest, Phillip1 aRustamov, Nabi1 aSwift, James1 aXie, Tao1 aAdamek, Markus1 aCho, Hohyun1 aWilson, Elizabeth1 aHan, Zhuangyu1 aBelsten, Alexander1 aLuczak, Nicholas1 aothers  uhttps://neurotechcenter.org/publications/2024/novel-theta-controlled-vibrotactile-brain%E2%80%93computer-interface-treat02052nas a2200313   4500008004100000022001400041245016300055210006900218260001200287300001100299490000700310520100100317100001901318700002001337700001801357700002301375700001601398700002401414700001701438700002201455700002101477700002001498700002201518700001901540700001901559700002401578700001901602856011701621       2022                        eng d  a1662-454800aToward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model.0 aToward a fully implantable ecosystem for adaptive neuromodulatio  c12/2022  a9327820 v163 a<p>This article describes initial work toward an ecosystem for adaptive neuromodulation in humans by documenting the experience of implanting CorTec's BrainInterchange (BIC) device in a beagle canine and using the BCI2000 environment to interact with the BIC device. It begins with laying out the substantial opportunity presented by a useful, easy-to-use, and widely available hardware/software ecosystem in the current landscape of the field of adaptive neuromodulation, and then describes experience with implantation, software integration, and post-surgical validation of recording of brain signals and implant parameters. Initial experience suggests that the hardware capabilities of the BIC device are fully supported by BCI2000, and that the BIC/BCI2000 device can record and process brain signals during free behavior. With further development and validation, the BIC/BCI2000 ecosystem could become an important tool for research into new adaptive neuromodulation protocols in humans.</p>1 aSchalk, Gerwin1 aWorrell, Samuel1 aMivalt, Filip1 aBelsten, Alexander1 aKim, Inyong1 aMorris, Jonathan, M1 aHermes, Dora1 aKlassen, Bryan, T1 aStaff, Nathan, P1 aMessina, Steven1 aKaufmann, Timothy1 aRickert, Jörn1 aBrunner, Peter1 aWorrell, Gregory, A1 aMiller, Kai, J  uhttps://neurotechcenter.org/publications/2022/toward-fully-implantable-ecosystem-adaptive-neuromodulation-humans