03128nas a2200433   4500008004100000022001400041245013100055210006900186260001200255300001100267490000800278520179900286653000902085653001002094653001502104653001902119653003002138653002302168653001802191653001102209653002902220100001702249700001902266700002202285700001902307700001702326700002602343700001802369700002702387700002002414700002102434700001802455700002102473700001702494700002402511700001902535700002002554856012002574       2023                        eng d  a1095-957200aComparisons of electrophysiological markers of impaired executive attention after traumatic brain injury and in healthy aging.0 aComparisons of electrophysiological markers of impaired executiv  c07/2023  a1201260 v2743 a<p>Executive attention impairments are a persistent and debilitating consequence of traumatic brain injury (TBI). To make headway towards treating and predicting outcomes following heterogeneous TBI, cognitive impairment specific pathophysiology first needs to be characterized. In a prospective observational study, we measured EEG during the attention network test aimed at detecting alerting, orienting, executive attention and processing speed. The sample (N = 110) of subjects aged 18-86 included those with and without traumatic brain injury: n = 27, complicated mild TBI; n = 5, moderate TBI; n = 10, severe TBI; n = 63, non-brain-injured controls. Subjects with TBI had impairments in processing speed and executive attention. Electrophysiological markers of executive attention processing in the midline frontal regions reveal that, as a group, those with TBI and elderly non-brain-injured controls have reduced responses. We also note that those with TBI and elderly controls have responses that are similar for both low and high-demand trials. In subjects with moderate-severe TBI, reductions in frontal cortical activation and performance profiles are both similar to that of controls who are ∼4 to 7 years older. Our specific observations of frontal response reductions in subjects with TBI and in older adults is consistent with the suggested role of the anterior forebrain mesocircuit as underlying cognitive impairments. Our results provide novel correlative data linking specific pathophysiological mechanisms underlying domain-specific cognitive deficits following TBI and with normal aging. Collectively, our findings provide biomarkers that may serve to track therapeutic interventions and guide development of targeted therapeutics following brain injuries.</p>10aAged10aAging10aBiomarkers10aBrain Injuries10aBrain Injuries, Traumatic10aExecutive Function10aHealthy Aging10aHumans10aNeuropsychological Tests1 aKim, Nayoung1 aJamison, Keith1 aJaywant, Abhishek1 aGaretti, Jacob1 aBlunt, Emily1 aRoyChoudhury, Arindam1 aButler, Tracy1 aDams-O'Connor, Kristen1 aKhedr, Shahenda1 aChen, Chun-Cheng1 aShetty, Teena1 aWinchell, Robert1 aHill, Jeremy1 aSchiff, Nicholas, D1 aKuceyeski, Amy1 aShah, Sudhin, A  uhttps://neurotechcenter.org/publications/2023/comparisons-electrophysiological-markers-impaired-executive-attention