01990nas a2200277   4500008004100000022001400041245005800055210005400113260001600167300000700183490000700190520119700197653001301394653001301407653001601420653001101436653001201447653003201459653002801491100001601519700001901535700002701554700001901581700001501600856009701615       2025                        eng d  a2052-446300aA human single-neuron dataset for object recognition.0 ahuman singleneuron dataset for object recognition  c2025 Jan 15  a790 v123 a<p>Object recognition is fundamental to how we interact with and interpret the world around us. The human amygdala and hippocampus play a key role in object recognition, contributing to both the encoding and retrieval of visual information. Here, we recorded single-neuron activity from the human amygdala and hippocampus when neurosurgical epilepsy patients performed a one-back task using naturalistic object stimuli. We employed two sets of naturalistic object images from leading datasets extensively used in primate neural recordings and computer vision models: we recorded 1204 neurons using the ImageNet stimuli, which included broader object categories (10 different images per category for 50 categories), and we recorded 512 neurons using the Microsoft COCO stimuli, which featured a higher number of images per category (50 different images per category for 10 categories). Together, our extensive dataset, offering the highest spatial and temporal resolution currently available in humans, will not only facilitate a comprehensive analysis of the neural correlates of object recognition but also provide valuable opportunities for training and validating computational models.</p>10aAmygdala10aEpilepsy10aHippocampus10aHumans10aNeurons10aPattern Recognition, Visual10aRecognition, Psychology1 aCao, Runnan1 aBrunner, Peter1 aBrandmeir, Nicholas, J1 aWillie, Jon, T1 aWang, Shuo  uhttps://neurotechcenter.org/publications/2025/human-single-neuron-dataset-object-recognition02590nas a2200325   4500008004100000022001400041245010900055210006900164260001600233300000900249490000700258520156700265653001001832653002301842653002701865653002401892653001301916653001101929653001801940100002101958700001801979700001601997700001902013700002502032700002102057700002302078700001902101700002502120856011902145       2024                        eng d  a2041-172300aMultisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges.0 aMultisensory flicker modulates widespread brain networks and red  c2024 Apr 11  a31560 v153 a<p>Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect of sensory flicker exposure on local field potential (LFP) power and interictal epileptiform discharges (IEDs) as primary and secondary outcomes, respectively. Flicker focally modulated local field potentials in expected canonical sensory cortices but also in the medial temporal lobe and prefrontal cortex, likely via resonance of stimulated long-range circuits. Moreover, flicker decreased interictal epileptiform discharges, a pathological biomarker of epilepsy and degenerative diseases, most strongly in regions where potentials were flicker-modulated, especially the visual cortex and medial temporal lobe. This trial met the scientific goal and is now closed. Our findings reveal how multi-sensory stimulation may modulate cortical structures to mitigate pathological activity in humans.</p>10aBrain10aCross-Over Studies10aElectroencephalography10aEpilepsies, Partial10aEpilepsy10aHumans10aTemporal Lobe1 aBlanpain, Lou, T1 aCole, Eric, R1 aChen, Emily1 aPark, James, K1 aWalelign, Michael, Y1 aGross, Robert, E1 aCabaniss, Brian, T1 aWillie, Jon, T1 aSinger, Annabelle, C  uhttps://neurotechcenter.org/publications/2024/multisensory-flicker-modulates-widespread-brain-networks-and-reduces