02032nas a2200193   4500008004100000245011900041210006900160260001200229520131200241100002101553700001601574700001601590700002501606700002101631700002301652700001901675700002501694856011901719       2023                        eng d00aMultisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges in Humans.0 aMultisensory Flicker Modulates Widespread Brain Networks and Red  c03/20233 a<p>Modulating brain oscillations has strong therapeutic potential. However, commonly used non-invasive interventions such as transcranial magnetic or direct current stimulation have limited effects on deeper cortical structures like the medial temporal lobe. Repetitive audio- visual stimulation, or sensory flicker, modulates such structures in mice but little is known about its effects in humans. Using high spatiotemporal resolution, we mapped and quantified the neurophysiological effects of sensory flicker in human subjects undergoing presurgical intracranial seizure monitoring. We found that flicker modulates both local field potential and single neurons in higher cognitive regions, including the medial temporal lobe and prefrontal cortex, and that local field potential modulation is likely mediated via resonance of involved circuits. We then assessed how flicker affects pathological neural activity, specifically interictal epileptiform discharges, a biomarker of epilepsy also implicated in Alzheimerâ€™s and other diseases. In our patient population with focal seizure onsets, sensory flicker decreased the rate interictal epileptiform discharges. Our findings support the use of sensory flicker to modulate deeper cortical structures and mitigate pathological activity in humans.</p>1 aBlanpain, Lou, T1 aChen, Emily1 aPark, James1 aWalelign, Michael, Y1 aGross, Robert, E1 aCabaniss, Brian, T1 aWillie, Jon, T1 aSinger, Annabelle, C  uhttps://neurotechcenter.org/publications/2023/multisensory-flicker-modulates-widespread-brain-networks-and-reduces