01678nas a2200277   4500008004100000022001400041245009700055210006900152260001200221300001000233490000800243520088300251653002201134653002101156653001301177653002501190653001601215653001501231653001801246653000801264100002301272700002101295700001501316700002101331856004801352       2001                        eng d  a0304-394000aEffects of chronic nerve cuff and intramuscular electrodes on rat triceps surae motor units.0 aEffects of chronic nerve cuff and intramuscular electrodes on ra  c10/2001  a1–40 v3123 aIn order to assess the long-term effects of implanted electrodes on motor unit properties, we studied triceps surae (TS) motor units in rats implanted for 3-10 months with a tibial nerve cuff electrode for H-reflex elicitation and intramuscular electrodes for recording TS electromyographic activity. Motor units with sag from implanted rats displayed greater tetanic force than those from unimplanted rats. Motor units without sag had shorter twitch contraction times. This disrupted the relationship between sag and contraction time that was always present in unimplanted rats. These differences were consistent with a small degree of muscle denervation and subsequent reinnervation. Further analyses ascribed this effect to the nerve cuff rather than to the intramuscular electrodes. Comparable changes in motor unit properties may occur in humans with implanted nerve cuffs.10achronic recording10acontraction time10aH-Reflex10aimplanted electrodes10amotor units10anerve cuff10areinnervation10asag1 aCarp, Jonathan, S.1 aChen, Xiang Yang1 aSheikh, H.1 aWolpaw, Jonathan  uhttp://www.ncbi.nlm.nih.gov/pubmed/11578831