<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jeremy Jeremy Hill</style></author><author><style face="normal" font="default" size="100%">Ricci, Erin</style></author><author><style face="normal" font="default" size="100%">Haider, Sameah</style></author><author><style face="normal" font="default" size="100%">McCane, Lynn M</style></author><author><style face="normal" font="default" size="100%">Susan M Heckman</style></author><author><style face="normal" font="default" size="100%">Jonathan Wolpaw</style></author><author><style face="normal" font="default" size="100%">Theresa M Vaughan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A practical, intuitive brain-computer interface for communicating 'yes' or 'no' by listening.</style></title><secondary-title><style face="normal" font="default" size="100%">J Neural Eng</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Neural Eng</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Algorithms</style></keyword><keyword><style  face="normal" font="default" size="100%">Auditory Perception</style></keyword><keyword><style  face="normal" font="default" size="100%">brain-computer interfaces</style></keyword><keyword><style  face="normal" font="default" size="100%">Communication Aids for Disabled</style></keyword><keyword><style  face="normal" font="default" size="100%">Electroencephalography</style></keyword><keyword><style  face="normal" font="default" size="100%">Equipment Design</style></keyword><keyword><style  face="normal" font="default" size="100%">Equipment Failure Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Man-Machine Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Quadriplegia</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword><keyword><style  face="normal" font="default" size="100%">User-Computer Interface</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">06/2014</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24838278</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">035003</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE:
Previous work has shown that it is possible to build an EEG-based binary brain-computer interface system (BCI) driven purely by shifts of attention to auditory stimuli. However, previous studies used abrupt, abstract stimuli that are often perceived as harsh and unpleasant, and whose lack of inherent meaning may make the interface unintuitive and difficult for beginners. We aimed to establish whether we could transition to a system based on more natural, intuitive stimuli (spoken words 'yes' and 'no') without loss of performance, and whether the system could be used by people in the locked-in state.
APPROACH:
We performed a counterbalanced, interleaved within-subject comparison between an auditory streaming BCI that used beep stimuli, and one that used word stimuli. Fourteen healthy volunteers performed two sessions each, on separate days. We also collected preliminary data from two subjects with advanced amyotrophic lateral sclerosis (ALS), who used the word-based system to answer a set of simple yes-no questions.
MAIN RESULTS:
The N1, N2 and P3 event-related potentials elicited by words varied more between subjects than those elicited by beeps. However, the difference between responses to attended and unattended stimuli was more consistent with words than beeps. Healthy subjects' performance with word stimuli (mean 77% ± 3.3 s.e.) was slightly but not significantly better than their performance with beep stimuli (mean 73% ± 2.8 s.e.). The two subjects with ALS used the word-based BCI to answer questions with a level of accuracy similar to that of the healthy subjects.
SIGNIFICANCE:
Since performance using word stimuli was at least as good as performance using beeps, we recommend that auditory streaming BCI systems be built with word stimuli to make the system more pleasant and intuitive. Our preliminary data show that word-based streaming BCI is a promising tool for communication by people who are locked in.</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Murguialday, A Ramos</style></author><author><style face="normal" font="default" size="100%">Jeremy Jeremy Hill</style></author><author><style face="normal" font="default" size="100%">Bensch, M</style></author><author><style face="normal" font="default" size="100%">Martens, S M M</style></author><author><style face="normal" font="default" size="100%">S Halder</style></author><author><style face="normal" font="default" size="100%">Nijboer, F</style></author><author><style face="normal" font="default" size="100%">Schoelkopf, Bernhard</style></author><author><style face="normal" font="default" size="100%">Niels Birbaumer</style></author><author><style face="normal" font="default" size="100%">Gharabaghi, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Transition from the locked in to the completely locked-in state: a physiological analysis.</style></title><secondary-title><style face="normal" font="default" size="100%">Clin Neurophysiol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Clin Neurophysiol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Amyotrophic Lateral Sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Area Under Curve</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain</style></keyword><keyword><style  face="normal" font="default" size="100%">Communication Aids for Disabled</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Electroencephalography</style></keyword><keyword><style  face="normal" font="default" size="100%">Electromyography</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Signal Processing, Computer-Assisted</style></keyword><keyword><style  face="normal" font="default" size="100%">User-Computer Interface</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">06/2011</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/20888292</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">122</style></volume><pages><style face="normal" font="default" size="100%">925-33</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;h4 style=&quot;font-size: 13px; margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 17px;&quot;&gt;OBJECTIVE:&amp;nbsp;&lt;/h4&gt;
&lt;p style=&quot;margin: 0px 0px 0.5em; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;To clarify the physiological and behavioral boundaries between locked-in (LIS) and the completely locked-in state (CLIS) (no voluntary eye movements, no communication possible) through electrophysiological data and to secure&amp;nbsp;&lt;span class=&quot;highlight&quot;&gt;brain-computer-interface&lt;/span&gt;&amp;nbsp;(&lt;span class=&quot;highlight&quot;&gt;BCI&lt;/span&gt;) communication.&lt;/p&gt;
&lt;h4 style=&quot;font-size: 13px; margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 17px;&quot;&gt;METHODS:&amp;nbsp;&lt;/h4&gt;
&lt;p style=&quot;margin: 0px 0px 0.5em; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;Electromyography from facial muscles, external anal sphincter (EAS), electrooculography and electrocorticographic data during different psychophysiological tests were acquired to define electrophysiological differences in an amyotrophic lateral sclerosis (ALS) patient with an intracranially implanted grid of 112 electrodes for nine months while the patient passed from the LIS to the CLIS.&lt;/p&gt;
&lt;h4 style=&quot;font-size: 13px; margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 17px;&quot;&gt;RESULTS:&amp;nbsp;&lt;/h4&gt;
&lt;p style=&quot;margin: 0px 0px 0.5em; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;At the very end of the LIS there was no facial muscle activity, nor external anal sphincter but eye control. Eye movements were slow and lasted for short periods only. During CLIS event related&amp;nbsp;&lt;span class=&quot;highlight&quot;&gt;brain&lt;/span&gt;potentials (ERP) to passive limb movements and auditory stimuli were recorded, vibrotactile stimulation of different body parts resulted in no ERP response.&lt;/p&gt;
&lt;h4 style=&quot;font-size: 13px; margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 17px;&quot;&gt;CONCLUSIONS:&amp;nbsp;&lt;/h4&gt;
&lt;p style=&quot;margin: 0px 0px 0.5em; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;The results presented contradict the commonly accepted assumption that the EAS is the last remaining muscle under voluntary control and demonstrate complete loss of eye movements in CLIS. The eye muscle was shown to be the last muscle group under voluntary control. The findings suggest ALS as a multisystem disorder, even affecting afferent sensory pathways.&lt;/p&gt;
&lt;h4 style=&quot;font-size: 13px; margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left; font-family: arial, helvetica, clean, sans-serif; line-height: 17px;&quot;&gt;SIGNIFICANCE:&amp;nbsp;&lt;/h4&gt;
&lt;p style=&quot;margin: 0px 0px 0.5em; font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;Auditory and proprioceptive&amp;nbsp;&lt;span class=&quot;highlight&quot;&gt;brain-computer-interface&lt;/span&gt;&amp;nbsp;(&lt;span class=&quot;highlight&quot;&gt;BCI&lt;/span&gt;) systems are the only remaining communication channels in CLIS.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hinterberger, T.</style></author><author><style face="normal" font="default" size="100%">Widman, Guido</style></author><author><style face="normal" font="default" size="100%">Lal, T.N</style></author><author><style face="normal" font="default" size="100%">Jeremy Jeremy Hill</style></author><author><style face="normal" font="default" size="100%">Tangermann, Michael</style></author><author><style face="normal" font="default" size="100%">Rosenstiel, W.</style></author><author><style face="normal" font="default" size="100%">Schölkopf, B</style></author><author><style face="normal" font="default" size="100%">Elger, Christian</style></author><author><style face="normal" font="default" size="100%">Niels Birbaumer</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Voluntary brain regulation and communication with electrocorticogram signals.</style></title><secondary-title><style face="normal" font="default" size="100%">Epilepsy Behav</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Epilepsy Behav</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Biofeedback, Psychology</style></keyword><keyword><style  face="normal" font="default" size="100%">Cerebral Cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Communication Aids for Disabled</style></keyword><keyword><style  face="normal" font="default" size="100%">Dominance, Cerebral</style></keyword><keyword><style  face="normal" font="default" size="100%">Electroencephalography</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsies, Partial</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Imagination</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Motor Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Motor Cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Signal Processing, Computer-Assisted</style></keyword><keyword><style  face="normal" font="default" size="100%">Software</style></keyword><keyword><style  face="normal" font="default" size="100%">Somatosensory Cortex</style></keyword><keyword><style  face="normal" font="default" size="100%">Theta Rhythm</style></keyword><keyword><style  face="normal" font="default" size="100%">User-Computer Interface</style></keyword><keyword><style  face="normal" font="default" size="100%">Writing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">08/2008</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/18495541</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">300-6</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span class=&quot;highlight&quot; style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;Brain-computer interfaces&lt;/span&gt;&lt;span style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;&amp;nbsp;(BCIs) can be used for communication in writing without muscular activity or for learning to control seizures by voluntary regulation of&amp;nbsp;&lt;/span&gt;&lt;span class=&quot;highlight&quot; style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;brain&lt;/span&gt;&lt;span style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;&amp;nbsp;signals such as the electroencephalogram (EEG). Three of five patients with epilepsy were able to spell their names with electrocorticogram (ECoG) signals derived from motor-related areas within only one or two training sessions. Imagery of finger or tongue movements was classified with support-vector classification of autoregressive coefficients derived from the ECoG signals. After training of the classifier, binary classification responses were used to select letters from a&amp;nbsp;&lt;/span&gt;&lt;span class=&quot;highlight&quot; style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;computer&lt;/span&gt;&lt;span style=&quot;font-family: arial, helvetica, clean, sans-serif; font-size: 13px; line-height: 17px;&quot;&gt;-generated menu. Offline analysis showed increased theta activity in the unsuccessful patients, whereas the successful patients exhibited dominant sensorimotor rhythms that they could control. The high spatial resolution and increased signal-to-noise ratio in ECoG signals, combined with short training periods, may offer an alternative for communication in complete paralysis, locked-in syndrome, and motor restoration.&lt;/span&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue></record></records></xml>