Title | Spinal and supraspinal effects of long-term stimulation of sensorimotor cortex in rats. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Chen, XY, Pillai, S, Chen, Y, Wang, Y, Chen, L, Carp, JS, Wolpaw, J |
Journal | Journal of neurophysiology |
Volume | 98 |
Pagination | 878–887 |
Date Published | 08/2007 |
ISSN | 0022-3077 |
Keywords | Time Factors |
Abstract | Sensorimotor cortex (SMC) modifies spinal cord reflex function throughout life and is essential for operant conditioning of the H-reflex. To further explore this long-term SMC influence over spinal cord function and its possible clinical uses, we assessed the effect of long-term SMC stimulation on the soleus H-reflex. In freely moving rats, the soleus H-reflex was measured 24 h/day for 12 wk. The soleus background EMG and M response associated with H-reflex elicitation were kept stable throughout. SMC stimulation was delivered in a 20-day-on/20-day-off/20-day-on protocol in which a train of biphasic 1-ms pulses at 25 Hz for 1 s was delivered every 10 s for the on-days. The SMC stimulus was automatically adjusted to maintain a constant descending volley. H-reflex size gradually increased during the 20 on-days, stayed high during the 20 off-days, and rose further during the next 20 on-days. In addition, the SMC stimulus needed to maintain a stable descending volley rose steadily over days. It fell during the 20 off-days and rose again when stimulation resumed. These results suggest that SMC stimulation, like H-reflex operant conditioning, induces activity-dependent plasticity in both the brain and the spinal cord and that the plasticity responsible for the H-reflex increase persists longer after the end of SMC stimulation than that underlying the change in the SMC response to stimulation. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/17522179 |
DOI | 10.1152/jn.00283.2007 |