Recent Publications

Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap.
Schiff ND, Diringer M, Diserens K, Edlow BL, Gosseries O, N Hill J, et al.. Brain-Computer Interfaces for Communication in Patients with Disorders of Consciousness: A Gap Analysis and Scientific Roadmap. Neurocrit Care. 2024;.
Variability of corticospinal and spinal reflex excitability for the ankle dorsiflexor tibialis anterior across repeated measurements in people with and without incomplete spinal cord injury.
Brangaccio JA, Phipps AM, Gemoets DE, Sniffen JM, Thompson AK. Variability of corticospinal and spinal reflex excitability for the ankle dorsiflexor tibialis anterior across repeated measurements in people with and without incomplete spinal cord injury. Exp Brain Res. 2024;.
Methods for automated delineation and assessment of EMG responses evoked by peripheral nerve stimulation in diagnostic and closed-loop therapeutic applications.
McKinnon ML, N Hill J, Carp JS, Dellenbach B, Thompson AK. Methods for automated delineation and assessment of EMG responses evoked by peripheral nerve stimulation in diagnostic and closed-loop therapeutic applications. J Neural Eng. 2023;20(4).
Characterization of High-Gamma Activity in Electrocorticographic signals
Gruenwald J, Sieghartsleitner S, Kapeller C, Scharinger J, Kamada K, Brunner P, et al.. Characterization of High-Gamma Activity in Electrocorticographic signals. Frontiers in Neuroscience [Internet]. 2023;17. https://www.frontiersin.org/articles/10.3389/fnins.2023.1206120
Unexpected sound omissions are signaled in human posterior superior temporal gyrus: an intracranial study
Cho H, Fonken YM, Adamek M, Jimenez R, Lin JJ, Schalk G, et al.. Unexpected sound omissions are signaled in human posterior superior temporal gyrus: an intracranial study. Cereb Cortex. 2023;33:8837–8848.
Comparisons of electrophysiological markers of impaired executive attention after traumatic brain injury and in healthy aging.
Kim N, Jamison K, Jaywant A, Garetti J, Blunt E, RoyChoudhury A, et al.. Comparisons of electrophysiological markers of impaired executive attention after traumatic brain injury and in healthy aging. Neuroimage. 2023;274:120126.
A motor association area in the depths of the central sulcus.
Jensen MA, Huang H, Valencia GOjeda, Klassen BT, van den Boom MA, Kaufmann TJ, et al.. A motor association area in the depths of the central sulcus. Nat Neurosci. 2023;26(7):1165-1169.
Intracranial stimulation and EEG feature analysis reveal affective salience network specialization.
Metzger BA, Kalva P, Mocchi MM, Cui B, Adkinson JA, Wang Z, et al.. Intracranial stimulation and EEG feature analysis reveal affective salience network specialization. Brain. 2023;.
Effects of active and sham tDCS on the soleus H-reflex during standing.
McCane LM, Wolpaw JR, Thompson AK. Effects of active and sham tDCS on the soleus H-reflex during standing. Exp Brain Res. 2023;241(6):1611-1622.
A somato-cognitive action network alternates with effector regions in motor cortex.
Gordon EM, Chauvin RJ, Van AN, Rajesh A, Nielsen A, Newbold DJ, et al.. A somato-cognitive action network alternates with effector regions in motor cortex. Nature. 2023;617(7960):351-359.
Data-efficient resting-state functional magnetic resonance imaging brain mapping with deep learning.
Luckett PH, Park KYun, Lee JJ, Lenze EJ, Wetherell JLoebach, Eyler LT, et al.. Data-efficient resting-state functional magnetic resonance imaging brain mapping with deep learning. J Neurosurg. 2023;:1-12.
Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges in Humans.
Blanpain LT, Chen E, Park J, Walelign MY, Gross RE, Cabaniss BT, et al.. Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges in Humans. medRxiv. 2023;.
Patients with Cognitive Impairment in Parkinson's Disease Benefit from Deep Brain Stimulation: A Case-Control Study.
Block CK, Patel M, Risk BB, Staikova E, Loring D, Esper CD, et al.. Patients with Cognitive Impairment in Parkinson's Disease Benefit from Deep Brain Stimulation: A Case-Control Study. Mov Disord Clin Pract. 2023;10(3):382-391.
Subsets of cortico-cortical evoked potentials propagate as traveling waves.
Campbell JM, Davis TS, Anderson DNesterovic, Arain A, Inman CS, Smith EH, et al.. Subsets of cortico-cortical evoked potentials propagate as traveling waves. bioRxiv. 2023;.
Towards clinical application of implantable brain-computer interfaces for people with late-stage ALS: medical and ethical considerations.
Vansteensel MJ, Klein E, van Thiel G, Gaytant M, Simmons Z, Wolpaw JR, et al.. Towards clinical application of implantable brain-computer interfaces for people with late-stage ALS: medical and ethical considerations. J Neurol. 2023;270(3):1323-1336.
Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography.
Nourmohammadi A, Swift JR, de Pesters A, Guay CS, Adamo MA, Dalfino JC, et al.. Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography. Clin Neurophysiol. 2023;147:31-44.
Altered cutaneous reflexes to non-noxious stimuli in the triceps surae of people with chronic incomplete spinal cord injury.
Phipps AM, Thompson AK. Altered cutaneous reflexes to non-noxious stimuli in the triceps surae of people with chronic incomplete spinal cord injury. J Neurophysiol. 2023;129(3):513-23.
Resting state network mapping in individuals using deep learning.
Luckett PH, Lee JJ, Park KYun, Raut RV, Meeker KL, Gordon EM, et al.. Resting state network mapping in individuals using deep learning. Front Neurol. 2023;13:1055437.
The human motor cortex contributes to gravity compensation to maintain posture and during reaching.
Hardesty RL, Ellaway PH, Gritsenko V. The human motor cortex contributes to gravity compensation to maintain posture and during reaching. J Neurophysiol. 2023;129(1):83-101.
Cognitive-Motor Dissociation Following Pediatric Brain Injury: What About the Children?
Kim N, O'Sullivan J, Olafson E, Caliendo E, Nowak S, Voss HU, et al.. Cognitive-Motor Dissociation Following Pediatric Brain Injury: What About the Children?. Neurol Clin Pract. 2022;12(3):248-257.
The Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders.
N Hill J, Gupta D, Eftekhar A, Brangaccio JA, Norton JJS, McLeod M, et al.. The Evoked Potential Operant Conditioning System (EPOCS): A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders. J Vis Exp. 2022;(186).
Operant down-conditioning of the soleus H-reflex in people after stroke.
Thompson AK, Gill CR, Feng W, Segal RL. Operant down-conditioning of the soleus H-reflex in people after stroke. Front Rehabil Sci. 2022;3:859724.
Workshops of the Eighth International Brain-Computer Interface Meeting: BCIs: The Next Frontier.
Huggins JE, Krusienski D, Vansteensel MJ, Valeriani D, Thelen A, Stavisky S, et al.. Workshops of the Eighth International Brain-Computer Interface Meeting: BCIs: The Next Frontier. Brain Comput Interfaces (Abingdon). 2022;9(2):69-101.
Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model.
Schalk G, Worrell S, Mivalt F, Belsten A, Kim I, Morris JM, et al.. Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model. Front Neurosci. 2022;16:932782.
Objective Neurophysiologic Markers of Cognition After Pediatric Brain Injury.
Kim N, Watson W, Caliendo E, Nowak S, Schiff ND, Shah SA, et al.. Objective Neurophysiologic Markers of Cognition After Pediatric Brain Injury. Neurol Clin Pract. 2022;12(5):352-364.
Heksor: the central nervous system substrate of an adaptive behaviour.
Wolpaw JR, Kamesar A. Heksor: the central nervous system substrate of an adaptive behaviour. J Physiol. 2022;600(15):3423-3452.
Automated intraoperative central sulcus localization and somatotopic mapping using median nerve stimulation.
Xie T, Wu Z, Schalk G, Tong Y, Vato A, Raviv N, et al.. Automated intraoperative central sulcus localization and somatotopic mapping using median nerve stimulation. J Neural Eng. 2022;.
Soleus H-reflex modulation during a double-legged drop landing task.
Lyle MA, McLeod MM, Pouliot BA, Thompson AK. Soleus H-reflex modulation during a double-legged drop landing task. Exp Brain Res. 2022;240(4):1093-1103.
Neural oscillations during motor imagery of complex gait: an HdEEG study.
Putzolu M, Samogin J, Cosentino C, Mezzarobba S, Bonassi G, Lagravinese G, et al.. Neural oscillations during motor imagery of complex gait: an HdEEG study. Sci Rep. 2022;12(1):4314.
Dynamics of Oddball Sound Processing: Trial-by-Trial Modeling of ECoG Signals.
Lecaignard F, Bertrand R, Brunner P, Caclin A, Schalk G, Mattout J. Dynamics of Oddball Sound Processing: Trial-by-Trial Modeling of ECoG Signals. Front Hum Neurosci. 2022;15:794654.
A neural population selective for song in human auditory cortex
Norman-Haignere SV, Feather J, Boebinger D, Brunner P, Ritaccio A, McDermott JH, et al.. A neural population selective for song in human auditory cortex. Current Biology [Internet]. 2022;32:1470-1484.e12. https://www.sciencedirect.com/science/article/pii/S0960982222001312
Overview
Overview

 
 
Neurological disorders affect hundreds of millions throughout the world. Recent engineering advances, combined with new scientific understanding enable creation of powerful neurotechnologies that interact with the nervous system to promote recovery. Engineers and scientists at the NIBIB/NIH-funded National Center for Adaptive Neurotechnologies (NCAN) are at the forefront of this exciting work. We are creating technologies that support real-time adaptive interactions with the nervous system that produce changes (plasticity) that enhances recovery for people with spinal cord injury, stroke, and other disorders. These technologies are producing new scientific insights and new clinical methods. We are disseminating these achievements to engineers, scientists, and clinicians everywhere.
 
Figure 1 summarizes NCAN structure. At the center is BCI2000, our unique general-purpose software platform now used by labs throughout the world. The inner ring comprises the three Technology Research and Development projects (TRDs) that develop and employ our technologies, particularly through their close interactions with distinguished collaborators everywhere. The outer ring includes our many training and dissemination activities.
 
NCAN has formulated a new conceptual paradigm that explains how skills are acquired and maintained in what is now understood to be a continually changing nervous system (Wolpaw & Kamesar 2022). This paradigm generates a comprehensive Triple-Strategy framework for combined-therapy protocols that restore skills impaired by CNS injury or disease. Guided by the paradigm and framework, NCAN is enhancing its core technologies to support combined-therapy protocols, hastening their clinical translation, and disseminating the technologies, protocols, and their principles to scientists, engineers, and clinicians everywhere.
 
TRD1 (Noninvasive Combined-Therapy Protocols in Humans) develops BCI2000-based technology that supports combined-therapy protocols in people with chronic spinal cord injury (SCI), stroke, or other disorders. These protocols enhance functional recovery significantly beyond that previously achieved, and this recovery persists after therapy ends.
 
TRD2 (Combined-Therapy Protocols in Animals) develops in rats BCI2000-based technology that implements promising combined-therapy protocols, evaluates their capacity to enhance functional recovery, examines mechanisms, and configures successful protocols for translation to human studies.
 
TRD3 (ECoG/SEEG-Based Combined-Therapy Protocols for Cognitive/Behavioral Disorders) is enabling development from intracranial measures of the effects of stimulation of BCI2000-based combined-therapy protocols that restore amygdala-mediated functions and alleviate post-traumatic stress disorder (PTSD) and other anxiety-related disorders.
 
NCAN offers many workshops in appropriate venues, provides training materials, guides other institutions in creating their own courses, and fosters creation of ongoing special interest groups. In sum, NCAN performs, encourages, and enables studies that increase understanding of CNS function and dysfunction, and realize effective new therapies for devastating neurological disorders.
 

Reference:

 

Wolpaw, J. R. and Kamesar, A., (2022). Heksor: The central nervous system substrate of an adaptive behaviour. The Journal of Physiology 600(15):3423–3452. ISSN 1469-7793. PMCID: PMC9545119.